KMID : 1130320060490101061
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Korean Journal of Pediatrics 2006 Volume.49 No. 10 p.1061 ~ p.1066
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Analysis of cow¡¯s milk specific IgE positive patients in newborns
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Lee Kil-Sang
Baek Nam-Kyung Kim Won-Duck
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Abstract
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Purpose:The purpose of this study was to research whether measurement of cow¡¯s milk specific IgE on the newborn would be helpful in the diagnosis of cow¡¯s milk allergy. We tried to find out the relation between cow¡¯s milk specific IgE and other allergy diseases by following up cases.
Methods:We reviewed clinical features of 87 episodes in infants less than 4 weeks old who were positive in cow¡¯s milk specific IgE test. For the study group, history taking, physical examinations, elimination and cow¡¯s milk specific IgE tests were carried out. We investigated the connection among cow¡¯ milk specific IgE, allergic disease and family history in 40 of 87 patients we could follow up on.
Results:The mean age of the study group was 17.2+/-5.4 days. The subjects were classified in four groups according into allergens : 87 milk allergy positive patients, 24 casein positive, 38 alpha-lactoalbumin positive, and 75 beta-lactoglobulin positive. The number of patients who had follow-ups for more than 6 months to was 40(45.9 percent). The patients whose parents had allergic disease numberred 10(25 percent). Fiften patients had allergic diseases, 4 had asthma and 11 atopic dermatitis. According to the follow-up study, there is a significant relation between casein positive patients and allergic disease. But there is no statistical and significant relation between cow¡¯s milk specific IgE and a family history of allergic disease.
Conclusion:For the newborn babies, elimination tests and cow¡¯s milk specific IgE tests can be useful in the diagnosis of IgE-mediated or mixed milk allergies.
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KEYWORD
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Newborn, Milk allergy, Immunoglobulin E
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